![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 11-Jul-2012[ | E-mail |
Share ] Contact: George Wigmore
g.wigmore@ucl.ac.uk
44-020-767-99041
University College London
Scientists have found that Native American populations from Canada to the southern tip of Chile arose from at least three migrations, with the majority descended entirely from a single group of First American migrants that crossed over through Beringia, a land bridge between Asia and America that existed during the ice ages, more than 15,000 years ago.
By studying variations in Native American DNA sequences, the international team found that while most of the Native American populations arose from the first migration, two subsequent migrations also made important genetic contributions. The paper is published in the journal Nature today.
"For years it has been contentious whether the settlement of the Americas occurred by means of a single or multiple migrations from Siberia," said Professor Andres Ruiz-Linares (UCL Genetics, Evolution and Environment), who coordinated the study. "But our research settles this debate: Native Americans do not stem from a single migration. Our study also begins to cast light on patterns of human dispersal within the Americas."
In the most comprehensive survey of genetic diversity in Native Americans so far, the team took data from 52 Native American and 17 Siberian groups, studying more than 300,000 specific DNA sequence variations called Single Nucleotide Polymorphisms to examine patterns of genetic similarities and differences between the population groups.
The second and third migrations have left an impact only in Arctic populations that speak Eskimo-Aleut languages and in the Canadian Chipewyan who speak a Na-Dene language. However, even these populations have inherited most of their genome from the First American migration. Eskimo-Aleut speakers derive more than 50% of their DNA from First Americans, and the Chipewyan around 90%. This reflects the fact that these two later streams of Asian migration mixed with the First Americans they encountered after they arrived in North America.
"There are at least three deep lineages in Native American populations," said co-author David Reich, Professor of genetics at Harvard Medical School. "The Asian lineage leading to First Americans is the most anciently diverged, whereas the Asian lineages that contributed some of the DNA to EskimoAleut speakers and the Na-Dene-speaking Chipewyan from Canada are more closely related to present-day East Asian populations."
The team also found that once in the Americas, people expanded southward along a route that hugged the coast with populations splitting off along the way. After divergence, there was little gene flow among Native American groups, especially in South America.
Two striking exceptions to this simple dispersal were also discovered. First, Central American Chibchan-speakers have ancestry from both North and South America, reflecting back-migration from South America and mixture of two widely separated strands of Native ancestry. Second, the Naukan and coastal Chukchi from north-eastern Siberia carry 'First American' DNA. Thus, Eskimo-Aleut speakers migrated back to Asia, bringing Native American genes.
The team's analysis was complicated by the influx into the hemisphere of European and African immigrants since 1492 and the 500 years of genetic mixing that followed. To address this, the authors developed methods that allowed them to focus on the sections of peoples' genomes that were of entirely Native American origin.
"The study of Native American populations is technically very challenging because of the widespread occurrence of European and African mixture in Native American groups," said Professor Ruiz-Linares.
"We developed a method to peel back this mixture to learn about the relationships among Native Americans before Europeans and Africans arrived," Professor Reich said, "allowing us to study the history of many more Native American populations than we could have done otherwise."
The assembly of DNA samples from such a diverse range of populations was only possible through a collaboration of an international team of 64 researchers from the Americas (Argentina, Bolivia, Brazil, Canada, Chile, Colombia, Costa Rica, Guatemala, Mexico, Peru, Russia and the USA), Europe (England, France, Spain and Switzerland) and Russia.
###
Notes for Editors
1. For more information, please contact Andres Ruiz-Linares on office number +44 (0)20 3108 4003, mobile +44 07900181839, e-mail a.ruizlin@ucl.ac.uk, or David Reich on office number +1 (617) 432-6548, e-mail: reich@genetics.med.harvard.edu.
2. Alternatively, please contact George Wigmore in the UCL Media Relations Office on tel: +44 (0)20 76799041, out of hours +44 (0)7917 271 364, e-mail: g.wigmore@ucl.ac.uk.
3. 'Reconstructing Native American population history' is published in the journal Nature on 1800 London time / 1300 US Eastern Time on 11 July 2012. Journalists can obtain copies of the paper by contacting UCL Media Relations.
About UCL (University College London)
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. We are among the world's top universities, as reflected by performance in a range of international rankings and tables. UCL currently has 24,000 students from almost 140 countries, and more than 9,500 employees. Our annual income is over 800 million.
http://www.ucl.ac.uk | Follow us on Twitter @uclnews
About HMS (Harvard Medical School)
Harvard Medical School (http://www.hms.harvard.edu) has more than 7,500 full-time faculty working in 11 academic departments located at the School's Boston campus or in one of 47 hospital-based clinical departments at 16 Harvard-affiliated teaching hospitals and research institutes. Those affiliates include Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Cambridge Health Alliance, Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Pilgrim Health Care, Hebrew SeniorLife, Joslin Diabetes Center, Judge Baker Children's Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Mount Auburn Hospital, Schepens Eye Research Institute, Spaulding Rehabilitation Hospital, and VA Boston Healthcare System.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 11-Jul-2012[ | E-mail |
Share ] Contact: George Wigmore
g.wigmore@ucl.ac.uk
44-020-767-99041
University College London
Scientists have found that Native American populations from Canada to the southern tip of Chile arose from at least three migrations, with the majority descended entirely from a single group of First American migrants that crossed over through Beringia, a land bridge between Asia and America that existed during the ice ages, more than 15,000 years ago.
By studying variations in Native American DNA sequences, the international team found that while most of the Native American populations arose from the first migration, two subsequent migrations also made important genetic contributions. The paper is published in the journal Nature today.
"For years it has been contentious whether the settlement of the Americas occurred by means of a single or multiple migrations from Siberia," said Professor Andres Ruiz-Linares (UCL Genetics, Evolution and Environment), who coordinated the study. "But our research settles this debate: Native Americans do not stem from a single migration. Our study also begins to cast light on patterns of human dispersal within the Americas."
In the most comprehensive survey of genetic diversity in Native Americans so far, the team took data from 52 Native American and 17 Siberian groups, studying more than 300,000 specific DNA sequence variations called Single Nucleotide Polymorphisms to examine patterns of genetic similarities and differences between the population groups.
The second and third migrations have left an impact only in Arctic populations that speak Eskimo-Aleut languages and in the Canadian Chipewyan who speak a Na-Dene language. However, even these populations have inherited most of their genome from the First American migration. Eskimo-Aleut speakers derive more than 50% of their DNA from First Americans, and the Chipewyan around 90%. This reflects the fact that these two later streams of Asian migration mixed with the First Americans they encountered after they arrived in North America.
"There are at least three deep lineages in Native American populations," said co-author David Reich, Professor of genetics at Harvard Medical School. "The Asian lineage leading to First Americans is the most anciently diverged, whereas the Asian lineages that contributed some of the DNA to EskimoAleut speakers and the Na-Dene-speaking Chipewyan from Canada are more closely related to present-day East Asian populations."
The team also found that once in the Americas, people expanded southward along a route that hugged the coast with populations splitting off along the way. After divergence, there was little gene flow among Native American groups, especially in South America.
Two striking exceptions to this simple dispersal were also discovered. First, Central American Chibchan-speakers have ancestry from both North and South America, reflecting back-migration from South America and mixture of two widely separated strands of Native ancestry. Second, the Naukan and coastal Chukchi from north-eastern Siberia carry 'First American' DNA. Thus, Eskimo-Aleut speakers migrated back to Asia, bringing Native American genes.
The team's analysis was complicated by the influx into the hemisphere of European and African immigrants since 1492 and the 500 years of genetic mixing that followed. To address this, the authors developed methods that allowed them to focus on the sections of peoples' genomes that were of entirely Native American origin.
"The study of Native American populations is technically very challenging because of the widespread occurrence of European and African mixture in Native American groups," said Professor Ruiz-Linares.
"We developed a method to peel back this mixture to learn about the relationships among Native Americans before Europeans and Africans arrived," Professor Reich said, "allowing us to study the history of many more Native American populations than we could have done otherwise."
The assembly of DNA samples from such a diverse range of populations was only possible through a collaboration of an international team of 64 researchers from the Americas (Argentina, Bolivia, Brazil, Canada, Chile, Colombia, Costa Rica, Guatemala, Mexico, Peru, Russia and the USA), Europe (England, France, Spain and Switzerland) and Russia.
###
Notes for Editors
1. For more information, please contact Andres Ruiz-Linares on office number +44 (0)20 3108 4003, mobile +44 07900181839, e-mail a.ruizlin@ucl.ac.uk, or David Reich on office number +1 (617) 432-6548, e-mail: reich@genetics.med.harvard.edu.
2. Alternatively, please contact George Wigmore in the UCL Media Relations Office on tel: +44 (0)20 76799041, out of hours +44 (0)7917 271 364, e-mail: g.wigmore@ucl.ac.uk.
3. 'Reconstructing Native American population history' is published in the journal Nature on 1800 London time / 1300 US Eastern Time on 11 July 2012. Journalists can obtain copies of the paper by contacting UCL Media Relations.
About UCL (University College London)
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. We are among the world's top universities, as reflected by performance in a range of international rankings and tables. UCL currently has 24,000 students from almost 140 countries, and more than 9,500 employees. Our annual income is over 800 million.
http://www.ucl.ac.uk | Follow us on Twitter @uclnews
About HMS (Harvard Medical School)
Harvard Medical School (http://www.hms.harvard.edu) has more than 7,500 full-time faculty working in 11 academic departments located at the School's Boston campus or in one of 47 hospital-based clinical departments at 16 Harvard-affiliated teaching hospitals and research institutes. Those affiliates include Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Cambridge Health Alliance, Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Pilgrim Health Care, Hebrew SeniorLife, Joslin Diabetes Center, Judge Baker Children's Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Mount Auburn Hospital, Schepens Eye Research Institute, Spaulding Rehabilitation Hospital, and VA Boston Healthcare System.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-07/ucl-nap070912.php
soylent green phil davis george st pierre aldon smith friday night lights nick santino bruce arians
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.